Vladimir J N Bykov Selected Research

2,2- bis(hydroxymethyl)- 1- azabicyclo(2,2,2,)octan- 3- one

5/2010	The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer.
7/2008	In vitro and in vivo cytotoxic effects of PRIMA-1 on hepatocellular carcinoma cells expressing mutant p53ser249.
1/2008	PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53.
12/2002	Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

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Vladimir J N Bykov Research Topics

Disease

19	Neoplasms (Cancer) 01/2021 - 03/2002
2	Hematologic Neoplasms (Hematological Malignancy) 01/2021 - 10/2012
2	Ovarian Neoplasms (Ovarian Cancer) 12/2018 - 01/2016
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2021
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2021
1	Breast Neoplasms (Breast Cancer) 12/2018
1	Open-Angle Glaucoma (Glaucoma, Open Angle) 10/2018
1	Cataract (Cataracts) 10/2018
1	Glaucoma 10/2018
1	Prostatic Neoplasms (Prostate Cancer) 10/2012
1	Confusion (Bewilderment) 10/2012
1	Dizziness (Lightheadedness) 10/2012
1	Fatigue 10/2012
1	Headache (Headaches) 10/2012
1	Uveal melanoma 07/2012
1	Hepatocellular Carcinoma (Hepatoma) 07/2008
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 07/2008

Drug/Important Bio-Agent (IBA)

7	eprenetapoptIBA 01/2021 - 05/2005
5	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 01/2003
4	2,2- bis(hydroxymethyl)- 1- azabicyclo(2,2,2,)octan- 3- oneIBA 05/2010 - 12/2002
3	Pharmaceutical PreparationsIBA 01/2021 - 03/2002
3	Proteins (Proteins, Gene)FDA Link 07/2012 - 12/2002
2	Sulfhydryl Compounds (Thiols)IBA 01/2021 - 01/2018
2	maleimideIBA 12/2017 - 08/2005
2	CP 31398IBA 06/2008 - 03/2002
1	Asparaginase (Elspar)FDA Link 01/2021
1	AsparagineIBA 01/2021
1	multidrug resistance-associated protein 1IBA 01/2021
1	RNA (Ribonucleic Acid)IBA 12/2018
1	Fluorouracil (Carac)FDA LinkGeneric 10/2018
1	AminoglycosidesIBA 01/2017
1	Biological ProductsIBA 10/2012
1	Tetracycline (Achromycin)FDA LinkGeneric 08/2005
1	1-(propoxymethyl)maleimideIBA 08/2005
1	Cisplatin (Platino)FDA LinkGeneric 05/2005
1	Transcription Factors (Transcription Factor)IBA 01/2003

Therapy/Procedure

11	Therapeutics 01/2021 - 01/2003
1	Percutaneous Collagen Induction 10/2018
1	Intravenous Infusions 10/2012
1	Treatment Delay 07/2008
1	Radiotherapy 08/2005
1	Drug Therapy (Chemotherapy) 08/2005